One-carbon metabolism refers to a network of interconnected biochemical pathways that are involved in the transfer of one-carbon units within cells. These pathways play a crucial role in various cellular processes, including DNA synthesis, amino acid metabolism, and lipid biosynthesis. One-carbon metabolism is essential for maintaining cellular health and is tightly regulated by enzymes and cofactors. Research in the field of one-carbon metabolism has been focused on understanding the regulation and function of these pathways in normal physiological processes as well as in diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders. By studying one-carbon metabolism, researchers aim to uncover potential therapeutic targets for treating these diseases and improving overall health outcomes. Overall, research in one-carbon metabolism is crucial for advancing our understanding of cellular metabolism and its role in human health and disease.